Faculty & School/Dept.
Faculty of Health - School of Kinesiology & Health Science
BSc - 2002
University of Guelph
MSc - 2003
University of Guelph
PhD - 2008
University of Guelph
Perry CGR*, Kane DA*, Lanza I, Neufer PD. Methods for assessing mitochondrial function in Diabetes. In review. Invited review, Diabetes.
Wan Z, Perry CGR, MacDonald T, Beaudoin MS, Castellani L, Chan CB, Schertzer J, Holloway GP, Wright DC. IL-6 is not necessary for the regulation of mitochondrial content in mouse adipose tissue. In review.
Smith BK, Perry CGR, Koves TR, Wright DC, Smith JC, Neufer PD, Muoio DM, Holloway GP. Identification of a novel malonyl-CoA IC50 for CPT-1: implications for predicting in vivo fatty acid oxidation rates. IN PRESS, Biochem J. 2012.
Perry CGR, Kane DA, Herbst EA, Mukai K, Wright DC, Heigenhauser GJF, Neufer PD, Spriet LL, Holloway GP. Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle. IN PRESS, JPHYSIOL/2012/234682, J Physiol. 2012. www.ncbi.nlm.nih.gov/pubmed/22907058
Kang L, Lustig ME, Bonner JS, Lee-Young RS, Mayes WH, James FD, Lin CT, Perry CGR, Anderson ET, Neufer PD, Wasserman DH. Mitochondrial anti-oxidative capacity regulates muscle glucose uptake during exercise in the conscious mouse: effect of exercise and diet. J Appl Physiol. doi: 10.1152/japplphysiol.01344.2011, 2012. www.ncbi.nlm.nih.gov/pubmed/22653994
Gurd BJ, Little JP, Perry CGR. Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments? Viewpoint. J Appl Physiol. 112: 926-928, 931, 2012. www.ncbi.nlm.nih.gov/pubmed/22383497
Perry CGR*, Kane DA*, Lin CT, Kozy R, Cathey B, Lark DS, Kane CL, Brophy P, Gavin T, Anderson EJ, Neufer PD. Inhibiting myosin-ATPase reveals dynamic range of mitochondrial respiratory control in skeletal muscle. Biochem J. 437: 215-222, 2011. www.ncbi.nlm.nih.gov/pubmed/21554250
Perry CGR, Lally J, Holloway GP, Bonen A, Heigenhauser GJ, Spriet LL. Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol. 588: 4795-4810, 2010. www.ncbi.nlm.nih.gov/pubmed/20921196
Gurd, BJ*, Perry CGR*, Spriet LL, Bonen A. High-intensity interval training increases SIRT1 activity in human skeletal muscle. Appl Physiol Nutr Metab. 35(3): 350-7, 2010. www.ncbi.nlm.nih.gov/pubmed/20555380
Perry CGR, Bonen A, Heigenhauser GJ, Spriet LL. High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletla muscle. Appl Physiol Nutr Metab. 33: 1112-1123, 2008. www.ncbi.nlm.nih.gov/pubmed/19088769
Spriet, LL, Perry CGR and Talanian JL. Legal pre-event nutritional supplements to assist energy metabolism. Essays Biochem. 44: 27-43, 2008.
Holloway GP, Perry CGR, Thrush AB, Heigenhauser GJ, Dyck DJ, Bonen A, Spriet LL. PGC-1alpha’s relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein. Am J Physiol Endocrinol Metab. 294(6): E1060-1069, 2008.
Perry CGR, Talanian JL, Heigenhauser GJF, Spriet LL. The effects of training in hyperoxia vs normoxia on skeletal muscle enzyme activities and exercise performance. J Appl Physiol. 102: 1022–1027, 2007.
Talanian JL, Tunstall RJ, Watt MJ, Duong M, Perry CGR, Steinberg GR, Kemp BE, Heigenhauser GJF, Spriet LL. Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise. Am J Physiol: Regul Integr & Comp Physiol 291: R1094-1099, 2006.
Perry CGR, Reid J, Perry WM, Wilson BA. Effects of hyperoxic training on performance and cardio-respiratory response to exercise. Med Sci Sports Exerc 37(7): 1175-1179, 2005.
*Contributed equally to investigation
Other Research Outputs
Selected conference abstracts
Castellani L, Perry CGR, Root-McCaig J, Wright DC (2012). Interleukin-6 and adipose tissue insulin resistance during the recovery from exercise. APS Integrative Biology of Exercise Meeting, Westminster, CO.
Lin CT, Fisher-Wellman KH, Perry CGR, Kozy R, Lark DS, Gilliam LAA, Smith CD, Neufer PD (2012). Low intensity exercise attenuates acute lipid loading-induced alterations in mitochondrial function in rat skeletal muscle. Experimental Biology Annual Conference, San Diego, CA.
Perry CGR, Kane DA, Lin CT, Kozy R, Cathey B, Lark DS, Kane CL, Brophy P, Gavin T, Anderson EJ, Neufer PD (2011). Inhibiting myosin-ATPase reveals dynamic range of mitochondrial respiratory control in permeabilized skeletal muscle fibres. National Heart, Lung and Blood Institute Mitochondrial Biology Symposium: Advances in Mitochondrial Dynamics and Mitochondrial-Cytosolic Communications. National Institutes of Health, Bethesda, MD.
Lin CT, Kane DA, Lark DS, Fisher-Wellman KH, Zheng D, Perry CGR, Kane CL, Kozy R, Tapscott EB, Ellis RJ, Woodlief TL, Neufer PD (2010). Β-GPA prevents high-fat induced mitochondrial H2O2 emission and insulin resistance independent of AMPK in mice. ACSM Integrative Physiology of Exercise. Miami Beach, FL. MSSE 42(10):22, 2010.
Lin CT, Lark DS, Kane DA, Anderson EJ, Tweedie CL, Perry CGR, Fisher-Welman KH, Neufer PD (2010). Metformin treatment protects against calcium-induced opening of the mitochondrial permeability transition pore in skeletal muscle of obese Zucker rats. American Diabetes Association Annual Conference, Orlando, FL.
Kang L, Lee-Young RS, Lustig ME, James FD, Lin CT, Perry CGR, Neufer PD, Wasserman DH (2010). Reduction of mitochondrial ROS by overexpression (OE) of antioxidants superoxide dismutase 2 (SOD2) and catalase increases muscle glucose uptake (MGU) during exercise (EX) in chow- and high fat (HF)-fed mice in vivo. American Diabetes Association Annual Conference, Orlando, FL.
Perry CGR, Kane DA, Lin CT, Anderson EJ, Neufer PD (2009). The effects of inhibiting contraction on ADP-stimulated respiratory kinetics in permeabilized myofibres. International Biochemistry of Exercise, Guelph, ON. Appl. Physiol. Nutr. Metab. 34: 1149.
Lin, CT, Kwon OS, Kane DA, Woodlief TL, Kwak HB, Price JW, Bikman BT, Hung JS, Perry CGR, Cortright RN, Neufer PD (2009). Exercise and β-GPA treatment prevent increased mitochondrial H2O2 emission and insulin resistance induced by high fat diet. International Biochemistry of Exercise, Guelph, ON. Appl. Physiol. Nutr. Metab. 34:1123.
Perry CGR, Lally J, Holloway GP, Bonen A, Heigenhauser GJ, Spriet LL (2009). Early transcriptional regulation of mitochondrial biogenesis during training in human skeletal muscle. International Biochemistry of Exercise, Guelph, ON. Appl. Physiol. Nutr. Metab. 34: 1149.
Kang L, Lustig ME, Anderson EJ, Lin CT, Perry CGR, Neufer PD, Wasserman DH (2009). Oxidative stress limits exercise-and insulin-stimulated muscle glucose uptake (MGU) in conscious, chow-fed C57BL/6J mice. Experimental Biology Annual Conference, New Orleans, LA. FASEB J 23: 990.32.
Canadian Society of Exercise Physiology
American Physiological Society
American College of Sports Medicine
Muscle Health Research Centre, Faculty of Health, York University
Currently available to supervise graduate students: Yes
Currently taking on work-study students, Graduate Assistants or Volunteers: Not Indicated
Available to supervise undergraduate thesis projects: Yes
Regulation of cellular energy and redox homeostasis primarily in skeletal muscle. Examination of metabolic control (glucose/fatty acid uptake and catabolism) through redox biology in response to specific dietary and exercise interventions integrating mitochondrial, cytosolic and nuclear intercommunication.
Acute metabolic control by diet/exercise is examined through regulation of specific enzymatic control points while chronic regulation is explored through regulation of gene expression. Focus is primarily on human skeletal muscle (muscle biopsies) and rodent models using advanced respirometric and fluorometric approaches to quantify cellular energy regulation and oxidant production. Future endeavours will integrate adipose tissue and hepatic metabolism with skeletal muscle for understanding how daily lifestyle (diet/exercise) affects systemic/whole body substrate metabolism primarily through redox biology in the context of metabolic health throughout the lifespan.