Faculty & School/Dept.
Faculty of Health - School of Kinesiology & Health Science
BSc - 2002
University of Guelph
MSc - 2003
University of Guelph
PhD - 2008
University of Guelph
Last 5 years
Monaco CMF*, Hughes MC*, Ramos SV, Varah NE, Lambzerz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ*, Perry CGR*. Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia. 2018 June; 61(6): 1411-1423. *These authors contributed equally to this investigation.
Song E., Ramos SV, Huang X, Liu Y, Botta A, Sung H, Turnbull P, Wheeler M, Berger T, Wilson D, Perry CGR, Mak TW, Sweeney G. Holo-Lipoclain-2 derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes. Proceedings of the National Academy of Sciences. 2018 Feb 13; 115(7): 1576-1581.
Pinho RA, Sepa-Kishi DM, Bikopoulos G, Wu MV, Uthayakumar A, Mohasses A, Hughes MC, Perry CGR, Ceddia RB. High-fat diet induces muscle oxidative stress in a fiber type-dependent manner. Free Radical Biology and Medicine (IF: 5.7). Accepted July 2017. FRBM-D-17-00238R1.
Monaco CMF, Perry CGR, Hawke TJ. Diabetic Myopathy - Current Molecular Understanding of this Novel Neuromuscular Disorder. Current Opinion in Neurology. Accepted June 2017. WCO300502
Perry CGR and Hawley JA. Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges. Invited review in ‘The Biology of Exercise’, Cold Harbor Springs Perspectives in Medicine. 2017 May 15: pii: a029686.
Mandel ER, Dunford EC, Abdifarkosh G, Turnbull PC, Perry CGR, Riddell MC, Haas TL. The superoxide dismutase mimetic Tempol does not alleviate glucocorticoid-mediated rarefaction of rat skeletal muscle capillaries. Physiological Reports. 2017 May 5(10): pii: e13243.
Perry CGR. Mitochondrial adaptations to exercise in human skeletal muscle: a possible role for cristae density as a determinant of muscle fitness. J Physiol. May 1: 595(9): 2773-2774, 2017. (Invited Perspectives)
Bhattacharya D, Ydfors M, Hughes MC, Norrbom J, Perry CGR, Scimè A. Decreased transcriptional co-repressor p107 is associated with exercise-induced mitochondrial biogenesis in human skeletal muscle. Physiological Reports. Mar 5(5). Pii: e13155, 2017.
Porras DP, Abbaszadeh M, Bhattacharya D, D’Sousa NC, Edjiu N, Perry CGR, Scimè A. p107 determines a metabolic checkpoint required for adipocyte lineage fates. Stem Cells. May: 35(5): 1378-1397, 2017.
Smith BK, Ford RJ, Desjardins EM, Green AE, Hughes MC, Houde VP, Day EA, Marcinko K, Crane JD, Motillo EP, Perry CGR, Kemp BE, Tarnopolsky MA, Steinberg GR. Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK β1. Diabetes. Nov: 65(11): 3352-3361, 2016.
MacPherson RE, Dragos SM, Ramos S, Sutton C, Frendo-Cumbo S, Castellani L, Watt MJ, Perry CGR, Mutch DM, Wright DC. Reduced ATGL-mediated lipolysis attenuates beta adrenergic induced AMPK signaling but not the induction of PKA targeted genes in adipocytes and adipose. Am J Physiol Cell Physiol. Aug 1: 311(2): C269-76, 2016.
Edgett BA, Hughes MC, Matusiak JBL, Perry CGR, Simpson CA, Gurd BJ. SIRT3 gene expression but not subcellular localization is altered in response to fasting and exercise in human skeletal muscle. Exp Physiol. Aug 1: 101(8): 1101-13, 2016.
Perry CGR, Wright DC. 2016. Challenging dogma: Is hepatic lipid accumulation in Type 2 Diabetes due to mitochondrial dysfunction? J Physiol. Aug 1: 594(15): 4093-4094, 2016. (Invited Perspectives)
Edgett BA, Scribbans TD, Raleigh JP, Matusiak JBL, Boonstra K, Simpson CA, Perry CGR, Quadrilatero J, Gurd BJ. The impact of a 48-hour fast on SIRT1 and GCN5 in human skeletal muscle. Appl Physiol Nutr Metab. Sept: 41(9): 953-62, 2016.
Ydfors M*, Hughes MC*, Laham R, Schlattner U, Norrbom J, Perry CGR. Modeling in vivo creatine/phosphocreatine in vitro reveal divergent adaptations in human muscle mitochondrial respiratory control by ADP post-exercise. J Physiol. Jun 1: 594(11): 3127-40, 2016. *These authors contributed equally to this investigation.
Hughes MC, Ramos SV, Turnbull PC, Nejatbakhsh A, Baechler BL, Tahmasebi H, Laham R, Gurd BJ, Quadrilatero J, Kane DA, Perry CGR. Mitochondrial bioenergetics and fibre type assessments in microbiopsy vs Bergstrom percutaneous sampling of human skeletal muscle. Frontiers in Physiology. Dec 18;6:360, 2015.
Castellani L, Perry CGR, MacPherson R, Root-McCaig J, Huber J, Arkell A, Simpson J, Wright DC. Exercise mediated IL-6 signaling occurs independent of inflammation and is amplified by training in mouse adipose tissue. JAPPL. Dec 1;119(11):1347-54, 2015.
Perry CGR. Is muscle hypertrophy following resistance exercise regulated by truncated splice variants of PGC-1 α? Acta Physiol Scand. Oct., 212(2): 122-4, 2014. PMID: 25042237. (Invited Perspectives).
Williams CB, Hughes MC, Edgett BA, Scribbans TD, Simpson CA, Perry CGR*, Gurd BJ. An examination of Resveratrol's mechanisms of action in human tissue: Impact of a single dose in vivo and dose responses in skeletal muscle ex vivo. PLoS ONE. 9(7): e102406, 2014. PMID: 25019209
De Sousa M, Porras DP, Perry CGR, Seale P, Scime A. p107 is a crucial regulator for determining the adipocyte lineage fate choices of stem cells. Stem Cells. May; 32(5): 1323-36, 2014. PMID: 24449206
Perry CGR*, Kane DA*, Lanza I, Neufer PD. Methods for assessing mitochondrial function in Diabetes. Invited Review, Diabetes. 62(4): 1041-1053, 2013. PMID: 23520284. *These authors contributed equally to this investigation.
Other Research Outputs
Canadian Society of Exercise Physiology
American Physiological Society
Muscle Health Research Centre, Faculty of Health, York University
Canadian Oxidative Stress Consortium
Member, Executive Directors
- Develop a forum for knowledge exchange for Canadian academics and students engaging in oxidative stress research across broad disciplines
Applied Physiology, Nutrition and Metabolism - Journal
Canadian Society of Exercise Physiology
- Develop initiatives that enhance the capacity of research in exercise physiology for Canadian academic and student members
Dean’s Award for Excellence in Research: Early Career - 2017
Currently available to supervise graduate students: Yes
Currently taking on work-study students, Graduate Assistants or Volunteers: Not Indicated
Available to supervise undergraduate thesis projects: Yes
Our laboratory investigates the regulation of skeletal muscle metabolism. Under this umbrella, we explore how a loss of normal metabolic regulation contributes to diseases that cause muscle weakness and limit exercise capacity. A major goal of our program is to develop novel therapeutic strategies to restore normal metabolic control and improve muscle fitness in disorders such as Duchenne muscular dystrophy and chemotherapy-induced muscle weakness. Through collaboration, we apply our expertise to understanding muscle health in other conditions such as Type 1 Diabetes.
Using a suite of human muscle biopsies, preclinical rodent models and cell culture, our approaches integrate direct measures of muscle fitness in skeletal muscle and diaphragm, diagnostic imaging of muscle volume and sub-cellular assessments of energy homeostasis. A major emphasis is placed on the regulation of mitochondrial bioenergetics as a central regulator of energy provision, oxidative stress and calcium homeostasis, and the manner by which these critical functions influence muscle function and mass.
We apply our mechanistic discoveries to developing therapies that improve muscle fitness through collaboration with international pharmaceutical partners and by modifying exercise therapy regimens within the constraints of specific disorders.
Our laboratory environment is enriched with multiple collaborations in diverse fields that span basic and applied sciences. We routinely host visiting trainees and share our mitochondrial bioenergetic and modified human muscle biopsy methodologies with laboratories across Canada, USA, Europe and Australia as well as through instructor roles at specialized international training workshops.
Our program is supported by NSERC Discovery, NSERC RTI, CFI/ORF, the James H Cummings Foundation and the Rare Disease Foundation.