Lauren E Sergio

Associate Professor

Coordinator, Neuroscience Graduate Diploma Program

Locations / Contact Info:

2032 Sherman Health Science Research Centre
Keele Campus
Phone (Office): 416 736 2100 Ext. 33641

Locations / Contact Info:

2010 Sherman Health Science Research Centre
Keele Campus
Phone (Lab): 416 736 2100 Ext. 33405

Email address(es):

Web site(s):

Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science


Ph.D. - 1994
McGill University

M.Sc - 1990
McGill University

BSc - 1988
McGill University


Dr. Sergio has studied the neural control of movement since 1988. After
completing a bachelor’s degree at McGill University in physiology, she did her Ph.D. there in psychology. Her research projects examine the effects of age, sex, neurological disease, head injury, and experience (elite versus non-elite  athletes) on the brain’s control of complex movement. Dr. Sergio works with a wide range of adult populations, including NHL draft prospects and Alzheimer’s disease patients, using behavioural and brain imaging techniques. Her funding has come primarily from NSERC and CIHR. She is also a member of the Centre for Vision Research, a research scientist at Southlake Regional Health Centre, a member of the York Lions Sport Medicine Team, and is currently the Neuroscience Graduate Diploma  program coordinator.

Selected Publications

Black A, Sergio LE, Macpherson AK  (2016) The Epidemiology of Concussions: Number and nature of concussions and time to recovery among female and male Canadian varsity athletes 2008-2011 Clinical Journal of Sport Medicine (in press)


Gorbet DJ, Sergio LE (i2015) The neural correlates of dissociating the spatial directions of eye and arm movements. Behav Brain Res. 2015 Nov 14. pii: S0166-4328(15)30283-7. doi: 10.1016/ j.bbr.2015.11.012


Brown J, Dalecki MS, Hughes C, Macpherson AK, Sergio LE (2015) Cognitive-motor integration deficits in young adult athletes following concussion. BMC Sports Science, Medicine, and Rehabilitation 2015 Oct 19;7:25. doi: 10.1186/s13102-015-0019-4.


Granek JA, Sergio LE (2015) Different brain pathways for strategic control versus sensorimotor recalibration: Evidence from a dual task reach paradigm. J. Neurophysiol. Aug;114(2):1298-309


Hawkins KL, Goyal A, Sergio LE (2015) Diffusion tensor imaging correlates of cognitive-motor decline in normal aging and increased Alzheimer’s disease risk. J. Alz. Dis. 44(3):867-878 (if:4.151).



Hawkins KL, Sergio LE (2014) Visuomotor impairments in older adults at increased Alzheimer’s disease risk. Journal of Alzheimer’s Disease. 42(2):607-621. (c:3)


Sayegh P, Hawkins KL, Neagu B, Crawford JD, Hoffman K, Sergio LE. (2014) Decoupling the actions of the eyes from the hand alters beta and gamma synchrony within SPL. J.Neurophysiol.June Vol. 111(2):2210-2221(c:2)


Granek JA, Pisella L, Vighetto A, Stemburger J, Rossetti Y, Sergio LE. (2013) Decoupled visually-guided reaching in optic ataxia: differences in motor control between canonical and non-canonical orientations in space. PLoS ONE 8(12): e86138.(if:4.411, c:3)


Sayegh P, Hawkins KL,  Hoffman KL,  Sergio LE (2013) Differences in sspectral profiles between rostral and caudal premotor cortex when hand-eye actions are decoupled. J. Neurophysiol. Aug:110(2):952-963. (c:3)


Hawkins KM, Sayegh P, Yan X, Crawford JD, Sergio LE (2013) Neural activity in superior parietal cortex during rule-based visual-motor transformations. J.Cogn.Neurosci. Mar;25(3):436-54.(if:5.357,c:13)


Tippett WJ, Alexander LD, Rizkalla MN, Sergio LE, Black SE. (2013) True functional ability of chronic stroke patients.J Neuroeng Rehabil. Feb 13;10(1):20. (if:2.74; c:2)


Granek JA, Pisella L, Blangero A, Rossetti Y, Sergio LE. (2012) The role of the superior parietal lobule in updating hand location in peripheral vision: further evidence from optic ataxia.PLoSOne, Oct;7(10):e46619. (c:12)


Tippett WJ ,Sergio LE ,Black SE (2012) Compromised visually guided motor control in individuals with Alzheimer's disease: can reliable distinctions be observed?J.Clin.Neurosci. 19(5):655-660.(if:1.378; c:10)


Salek Y, Anderson N, Sergio LE (2011)  Mild cognitive impairment is associated with impaired visual-motor planning when visual stimuli and actions are incongruent. Eur. Neurol. 66(5):283-293. (if:1.356; c7)



Sergio LE, Gorbet DJ, Tippett WJ, Yan X, Neagu B (2009) When what you see isn’t where you get: cortical mechanisms of  vision for complex action. In: Cortical Mechanisms of Vision. London: Cambridge University Press. March 2009

Kalaska JF, Sergio LE, Cisek P (1998) Cortical control of whole-arm motor tasks. In: Sensory Guidance of Movement, Vol. 218, Novartis Foundation Symposium. New York: John Wiley & Sons,  pp. 176-200.

Granek J, Gorbet DJ, Sergio LE (2010) Extensive video game experience alters the cortical networks for complex visually-guided reaching. Cortex Oct. 46(9): 1165-1177.

Pisella L, Sergio LE, Blangero A, Torchin H, Vighetto A,  Rossetti Y (2009) Optic Ataxia and the functions of the dorsal stream: When does the dorsal stream contribute to perception and action. Neuropsychologia, Dec; 47(14): 3033-44.

Gorbet DJ, Sergio LE (2009) The behavioral consequences of dissociating the spatial directions of eye and arm movements I: The effects of anti-pointing. Brain Research, Aug 11;1284:77-88.

Gorbet DJ, Sergio LE (2007)  Sex-related differences in cortical activity during visually-guided movements. Eur. J. Neurosci. Feb;25:1228-1239.

Tippett WJ, Krajewski A, Sergio LE (2007) Visuomotor integration is compromised in Alzheimer's disease patients reaching to remembered targets Eur. Neurology. May; 58(1):1-11. 

Hamel-Paquet C, Sergio LE,  Kalaska JF (2006). Parietal area 5 activity does not reflect the differential time course of motor output kinetics during arm-reaching and isometric-force tasks. J. Neurophysiol. 95: 3353-3370.

Sergio LE, Hamel-Paquet C, Kalaska JF. (2005) Motor cortex neural correlates of output kinematics and kinetics during isometric-force and arm-reaching tasks. J Neurophysiol. 94: 2353-2378.

Vesia M, Vander H, Yan X, and  Sergio, LE. (2005) The time course for kinetic versus kinematic planning of goal-directed human motor behavior. Exp Brain Res. Jan;160(3):290-301.

Gorbet DJ, Staines WR, Sergio LE (2004) An fMRI study of cortical activity during progressively arbitrary visuomotor transformations. Neuroimage: Nov;23(3):1100-11.

Petitto LA, Holowka S, Sergio LE, Levy B, Ostry D (2004) Baby hands that move to the rhythm of language: hearing babies acquiring sign languages babble silently on the hands. Cognition  Aug;93:43-73.

Sergio LE, Kalaska JF (2003) Systematic changes in motor cortex cell activity with arm posture during directional isometric force generation. J. Neurophysiol. 89:212-228.

Petitto LA, Holowka S, Sergio LE, Ostry D (2001) Language rhythms in baby hand movements. Nature 413:35-36.

Sergio LE, Kalaska JF (1998) Changes in the temporal pattern of primary motor cortex activity in a directional isometric force versus limb movement task. J. Neurophysiol. 80:1577-1583.

Sergio LE, Scott SH (1998) Hand and joint paths during reaching movements with and without vision. Exp. Br. Res. 122:157-164.

Scott SH, Sergio LE, Kalaska JF (1997)  Reaching movements with similar hand paths but different arm orientations. II. Activity of individual cells in dorsal premotor and parietal area 5 cortex. J. Neurophysiol. 78(5):2413‑2426.

Sergio LE, Kalaska JF (1997) Systematic changes in directional tuning of motor cortex cell activity with hand location in the workspace during generation of static isometric forces in constant spatial directions. J. Neurophysiol. 78: 1170-1174.

Sergio LE, Ostry DJ (1995) Coordination of multiple muscles in two degree of freedom elbow movements. Exp. Br. Res. 105: 123-137.

Sergio LE, Ostry DJ (1994) Coordination of mono- and bi-articular muscles in multi-degree of freedom elbow movements. Exp. Br. Res. 97: 551-555.

Service/Community Activities

Careers in Science Day, Middlefield Collegiate
Science Fair Judge


Currently available to supervise graduate students: Yes

Currently taking on work-study students, Graduate Assistants or Volunteers: Yes

Available to supervise undergraduate thesis projects: Yes

Current Research

Behavioural and neurophysiological studies of eye-limb coordination. Brain mechanisms underlying visually-guided reaching. Cognitive-motor integration; Motor control neurophysiology/neuroimaging. Control of voluntary movement in healthy adults, elite athletes, and neurological patient populations. Sex-related differences in brain function for movement control. Applications: Neuropathology detection/diagnosis/rehabilitation, especially for dementia populations; evaluation of eye-hand coordination in elite athletes; Long-term effects of concussion on skilled performance.

Curriculum Vitae (C.V. file):

CV of Lauren E Sergio