David A Hood


NSERC Tier 1 Canada Research Chair in Cell Physiology

Locations / Contact Info:

302A Farquharson Life Sciences - FARQ
Keele Campus
Phone: 416 736 2100 Ext. 66640

Locations / Contact Info:

302 Farquharson Life Sciences - FARQ
Keele Campus
Phone: 416 736 2100 Ext. 77832

Email address(es):


Web site(s):

Hood Lab Website
Muscle Health Research Centre Website

Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science


Ph.D Physiology - 1986
State University of New York

B.A. Physical & Health - 1979
Queen's University

M.Sc Physical Education - 1981
Dalhousie University

B.P.H.Education - 1979
Queen's University

Selected Publications

Papers in refereed journals  

Hornberger T.A., H.N. Carter, D.A. Hood, V.C. Figueiredo, E.E. Dupont-Versteegden, C.A. Peterson, J.J. McCarthy, D.M. Camera, J.A. Hawley, T. Chaillou, A.J. Cheng, G.A. Nader, R.C. Wust, R.H. Houtkooper. Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough. J. Appl. Physiol. 121:597-600, 2016.

Crilly, M.J., L.D. Tryon, A.T. Erlich and D.A. Hood. The role of Nrf2 in skeletal muscle contractile and mitochondrial function. J. Appl. Physiol. 121(3):730-40, 2016.

Hood, D.A., L.D. Tryon, H.N. Carter, Y. Kim and C.C.W. Chen. Unraveling the mechanisms regulating muscle mitochondrial biogenesis. Biochem. J. 473(15):2295-314, 2016.

Erlich, A.T., L.D. Tryon, M.J. Crilly, J. M. Memme, Z. S. Mesbah Moosavi, A.N. Oliveira, K. Beyfuss and D.A. Hood. Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis.  Integr. Med. Res. 5(3):187-197, 2016.

Memme, J., A. Oliveira and D.A. Hood.  The chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity.  Am. J. Physiol. Cell Physiol. 310: C1024-C1036, 2016.

Vainshtein, A. and D.A. Hood. The regulation of autophagy during exercise in skeletal muscle. J. Appl. Physiol. 120: 664-673, 2016.

Hood, D.A., L.D. Tryon, A. Vainshtein, J. Memme, C. Chen, M. Pauly, M.J. Crilly and H. Carter, Exercise and the Regulation of Mitochondrial Turnover. In: Claude Bouchard (Ed.), Progress in Molecular Biology and Translational Science, 135: 99-127, 2015.

Tryon, L.D., M.J. Crilly and D.A. Hood.  Effect of denervation on the regulation of mitochondrial transcription factor A expression in skeletal muscle. Am. J. Physiol. Cell Physiol. 309: C228-38, 2015.

Collu-Marchese, M., M. Shuen, M. Pauly, A. Saleem and D.A. Hood. The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation. Bioscience Reports 35: e00221, DOI: 10.1042/BSR20150073, 2015.  

Carter, H.N., C.C.W. Chen and D.A. Hood. Mitochondria, Muscle Health and Exercise with Advancing Age.  Physiology 30:208-223, 2015.

Vainshtein, A., E.M. Desjardins, A. Armani, M. Sandri, and D.A. Hood. PGC-1α modulates denervation-induced mitophagy in skeletal muscle. Skeletal Muscle 5:9, 2015.

Vainshtein, A., L.D. Tryon, M. Pauly, and D.A. Hood. The role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle.  Am. J. Physiol. Cell Physiol. 308:C710-C719, 2015.

Chapters in books

Zhang, Y., L.D. Tryon and D.A. Hood. Absence of Bax and Bak: Implications for autophagy and alternative mitochondrial functions. In Hayat, M.A. (Ed.) Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging: Vol. 9. Human Diseases and Autophagosome. Elsevier, 2016, Chapter 7, pp. 155-164.

Hood, D.A., A. Saleem, H. Carter, A. Vainshtein, O. Ostojic, and S. Iqbal.  Molecular basis of exercise training adaptations in skeletal muscle.  In: MacIntosh, B.M. (Ed.).  Exercise Physiology in Canada. Toronto: McGraw-Hill, Chpt. 14 (in review).

Hood, D.A., M.F.N. O'Leary, G. Uguccioni and I. Irrcher.  Metabolic Systems: Mitochondrial Mitochondrial Biogenesis induced by Endurance Training. In: Farrell, P.A., M.J. Joyner and V.J. Caiozzo (Eds). ACSM Graduate Textbook of Exercise Physiology.  Baltimore: Lippincott, Williams and Wilkens Chapter 18, pp. 447-465, 2012.

Hood, D.A. and K. Singh. Mitochondrial Biogenesis. In: Mooren, F.C. and J.S. Skinner (Eds) Encyclopedia of Exercise Medicine and Disease. Heidelburg: Springer Verlag,, 2012.

Saleem, A., L. Kazak, M.O’Leary, and D.A. Hood. Muscle. In: J.C. Reed and D. Green D (Eds.) Apoptosis: Physiology and Pathology of Cell Death New York: Cambridge University Press, pp. 313-322, 2011.

Hood D.A. Physical activity and skeletal muscle biology. In: Bouchard, C. and P. Katzmarzyk (Eds.) Advances in Physical Activity and Obesity Champaign, IL: Human Kinetics Pubs. Chpt. 42, pp. 170-173, 2010.

Joseph, A.-M. V. Ljubicic, K. Menzies, L. Kazak, G. Uguccioni, and D.A. Hood Mitochondrial biogenesis in health and disease-influence of stress stimuli. In: J. Magalhaes and A. Ascensao (Eds.) Muscle Plasticity: Advances in Physiological and Biochemical Research. Kerala: The Research Signpost/ Transworld Research Network, pp. 151-171, 2009.

Hood, D.A., B. Chabi, K. Menzies, M. O’Leary and D. Walkinshaw. Exercise-induced mitochondrial biogenesis in skeletal muscle.  In: Stocchi, V., P. DeFeo and D.A. Hood (Editors).Role of Physical Exercise in Preventing Disease and Improving the Quality of Life. Milan:Springer-Verlag Italia, pp. 37-60, 2007.

Hood, D.A., and I. Irrcher.  Metabolic Systems: Muscle Mitochondrial Biogenesis. Tipton, CM and C.A. Tate (Eds). ACSM Graduate Textbook of Exercise Physiology.  Baltimore: Lippincott, Williams and Wilkens pp. 437-452, 2006.


Muscle Health Research Centre, Faculty of Health, York University


York University Faculty of Health Established Career Research Award - 2009

Canadian Society for Exercise Physiology (CSEP) Honour Award - 2010

Distinguished Visiting Professor, Heart & Stroke / Richard Lewar Centre of Excellence in Cardiovascular Research - 2013

Peter A. Rechnitzer Lecturer, Centre for Physical Activity and Aging, Western University - 2013

York University Faculty of Health Established Career Research Award - 2013

Adam Barsky Lectureship on Mitochondrial Diseases, Hospital for Sick Children - 2014

Canadian Society for Exercise Physiology (CSEP) John R. Sutton Lecturer - 2015


Currently available to supervise graduate students:

Currently taking on work-study students, Graduate Assistants or Volunteers:

Available to supervise undergraduate thesis projects:

Current Research

Skeletal muscle and heart biochemistry and molecular biology; mitochondrial adaptations in muscle subject to chronic contractile activity, including mechanisms of mitochondrial protein import and nuclear gene expression; cardiac muscle adaptations to thyroid hormone.