Mazen J Hamadeh

Associate Professor

Locations / Contact Info:

220 Lumbers - LUM
Keele Campus
Phone: 416 736 2100 Ext. 33552

Email address(es):

hamadeh@yorku.ca

Web site(s):

http://www.yorku.ca/hamadeh/

Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science

Degrees

PhD -
McGill University
Montreal

MSc -
American University of Beirut
Beirut, Lebanon

MSc -
University of Toronto
Toronto

BSc -
American University of Beirut
Beirut, Lebanon

Biography

Selected Publications



PEER-REFEREED JOURNAL PUBLICATIONS



1.         Gianforcaro A, Solomon JA, Hamadeh MJ. Vitamin D3 at 50x AI attenuates the decline in paw grip endurance, but not disease outcomes, in the G93A mouse model of ALS, and is toxic in females. PLoS ONE 2013;8:e30243. doi:10.1371/journal.pone.0030243 http://dx.plos.org/10.1371/journal.pone.0030243


 


2.         Abramovitch SL, Reddigan JI, Hamadeh MJ, Jamnik VK, Rowan CP, Kuk JL. Estimating serving sizes and food intake using Canada’s Food Guide. Appl Physiol Nutr Metab 2012;37:923-30. doi:10.1139/H2012-071 http://www.nrcresearchpress.com/doi/abs/10.1139/h2012-071


 


3.         Gianforcaro A, Hamadeh MJ. Vitamin D3 supplementation at 10x the adequate intake attenuates functional decline in the G93A transgenic mouse model of ALS, a pilot study. CNS Neurosci Ther 2012;18(7):547-57.   doi: 10.1111/j.1755-5949.2012.00316.x                


http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2012.00316.x/abstract;jsessionid=E04AF21EFB09E218D1727AC3A36811FF.d03t03


 


4.         Ma X, Hamadeh MJ, Christie BR, Foster JA, Tarnopolsky MA. Impact of treadmill running and sex on hippocampal neurogenesis in the mouse model of amyotrophic lateral sclerosis. PLoS One 2012;7(4):e36048. doi:10.1371/journal.pone.0036048   http://dx.plos.org/10.1371/journal.pone.0036048


 


5.         Al-Sahab B, Ardern C, Hamadeh MJ, Tamim H. Age at menarche and current substance use among Canadian adolescent girls: Results of a cross-sectional study. BMC Public Health 2012;12:195. doi:10.1186/1471-2458-12-195 http://www.biomedcentral.com/1471-2458/12/195/abstract


 


6.         Solomon JA, Gianforcaro A, Hamadeh MJ. Vitamin D3 deficiency differentially affects functional and disease outcomes in the G93A mouse model of amyotrophic lateral sclerosis. PLoS ONE 2011;6:e29354. doi:10.1371/journal.pone.0029354 http://dx.plos.org/10.1371/journal.pone.0029354


 


7.         Solomon JA, Tarnopolsky MA, Hamadeh MJ. One universal common endpoint in mouse models of amyotrophic lateral sclerosis. PLoS ONE 2011;6:e20582. doi:10.1371/journal.pone.0020582 http://dx.plos.org/10.1371/journal.pone.0020582


 


8.         Al-Sahab B, Adair L, Hamadeh MJ, Ardern C, Tamim H. Impact of breastfeeding duration on age at menarche. Am J Epidemiol 2011;173:971-7. doi:10.1093/aje/kwq496 The journal invited a commentary on this article. http://aje.oxfordjournals.org/content/173/9/971.long


 


9.         Al-Sahab B, Hamadeh MJ, Ardern C, Tamim H. Early menarche predicts incidence of asthma in early adulthood. Am J Epidemiol 2011;173(1):64-70. doi:10.1093/aje/kwq324 http://aje.oxfordjournals.org/content/173/1/64.long


 


10.     Al-Sahab B, Ardern C, Hamadeh MJ, Tamim H. Age at menarche in Canada: results from the national longitudinal survey of children and youth. BMC Public Health 2010;10:736. doi:10.1186/1471-2458-10-736  http://www.biomedcentral.com/1471-2458/10/736


 


11.     Moreira TS, Hamadeh MJ. The role of vitamin D deficiency and low calcium/dairy intake in the pathogenesis of type 2 diabetes mellitus. e-SPEN Eur e-J Clin Nutr Metab 2010;5:e155-e165. doi: 10.1016/j.eclnm.2010.05.001 http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B83WT-508XBD9-1-5&_cdi=33795&_user=866177&_pii=S1751499110000302&_orig=browse&_coverDate=08%2F31%2F2010&_sk=999949995&view=c&wchp=dGLzVtz-zSkWb&md5=ce175f8ea0e74513432fb9dd30bce0a2&ie=/sdarticle.pdf


 


12.     Safdar A, Hamadeh MJ, Kaczor JJ, Raha S, deBeer J, Tarnopolsky MA. Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults. PLoS ONE 2010;5:e10778. doi:10.1371/journal.pone.0010778  http://dx.plos.org/10.1371/journal.pone.0010778


 


13.     Patel BP, Safdar A, Raha S, Tarnopolsky MA, Hamadeh MJ. Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of amyotrophic lateral sclerosis. PLoS ONE 2010;5:e9386. doi:10.1371/journal.pone.000938 http://dx.plos.org/10.1371/journal.pone.0009386


 


14.     Crane JD, Devries MC, Safdar A, Hamadeh MJ, Tarnopolsky MA. The effect of aging on human skeletal muscle mitochondrial and IMCL ultrastructure. J Gerontol A Biol Sci Med Sci 2010;65:119-28.


 


15.     Fu M-H, Maher A, Hamadeh MJ, Ye C, Tarnopolsky MA. Exercise, sex, menstrual cycle phase and 17β-estradiol influence metabolism related genes in human skeletal muscle. Physiol Genomics 2009;40:34-47.


 


16.     Patel BP, Hamadeh MJ. Nutritional and exercise-based interventions in the treatment of amyotrophic lateral sclerosis. Clin Nutr 2009;28:604-17 (Impact factor, 3.27).


 


17.     Seevaratnam R, Patel BP, Hamadeh MJ. Comparison of total protein concentration in skeletal muscle as measured by the Bradford and the Lowry assays. J Biochem 2009;145:791–7.


 


18.     Timmons BW, Hamadeh MJ, Tarnopolsky MA. Two methods for determining plasma IL-6 in humans at rest and following exercise. Eur J Appl Physiol 2009;105:13-8.


 


19.     Devries MC, Samjoo IA, Hamadeh MJ, Tarnopolsky MA. Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women. Obesity 2008;16:2281-8.


 


20.     Devries MC, Hamadeh MJ, Glover AW, Raha S, Samjoo IA, Tarnopolsky MA. Endurance training without weight loss lowers systemic, but not muscle, oxidative stress with no effect on inflammation in lean and obese women. Free Radic Biol Med 2008;45:503-11.


 


21.     Lord HL, Rosenfeld J, Raha S, Hamadeh MJ. Automated derivatization and analysis of malondialdehyde using column switching sample preparation HPLC with fluorescence detection. J Sep Sci 2008;31:387-401.


 


22.     Devries MC, Lowther SA, Glover AW, Hamadeh MJ, Tarnopolsky MA.  IMCL area density, but not IMCL utilization, are higher in women during moderate intensity endurance exercise as compared with men. Am J Physiol Regul Integr Comp Physiol 2007;293:R2336-42.


 


23.     Tarnopolsky MA, Rennie CD, Robertshaw HA, Fedak-Tarnopolsky SN, Brose AN, Devries MC, Hamadeh MJ.  The influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure.  Am J Physiol Regul Integr Comp Physiol 2007;292:R1271-8.


 


24.     Hamadeh MJ, Tarnopolsky MA. Transient caloric restriction in early adulthood hastens disease endpoint in male, but not female, Cu/Zn-SOD mutant G93A mice. Muscle Nerve 2006;34:709-19. (Impact factor, 2.594; Cited once)


 


25.     Devries MC, Hamadeh MJ, Phillips SM, Tarnopolsky MA.  Menstrual cycle phase and sex influence muscle glycogen utilization and glucose Ra, Rd, and MCR during moderate intensity endurance exercise.  Am J Physiol Regul Integr Comp Physiol 2006;291:1120-8.


 


26.     Timmons BW, Hamadeh MJ, Tarnopolsky MA.  No effect of short-term 17-b-estradiol supplementation in healthy men on systemic inflammatory responses to exercise.  Am J Physiol Regul Integr Comp Physiol 2006;291:R285-90.


 


27.     Devries MC, Hamadeh MJ, Graham TE, Tarnopolsky MA.  17-β-estradiol supplementation decreases glucose Ra and Rd with no effect on glycogen utilization during moderate intensity exercise in men.  J Clin Endocrinol Metab 2005;90:6218-25.


 


28.     Hoffer LJ, Hamadeh MJ, Robitaille L, Norwich KH.  Human sulfate kinetics.  Am J Physiol Regul Integr Comp Physiol 2005;289:R1372-80.


 


29.     Timmons BW, Hamadeh MJ, Devries MC, Tarnopolsky MA.  Influence of gender, menstrual phase and oral contraceptive use on immunological changes in response to prolonged cycling.  J Appl Physiol 2005;99:979-85.


 


30.     Hamadeh MJ, Devries MC, Tarnopolsky MA. Estrogen supplementation reduces whole body leucine and carbohydrate oxidation and increases lipid oxidation in men during endurance exercise.  J Clin Endocrinol Metab 2005;90:3592-9. (Impact factor, 6.325; Cited 24 times)


 


31.     Hamadeh MJ, Rodriguez MC, Kaczor JJ, Tarnopolsky MA.  Caloric restriction transiently improves motor performance but hastens clinical onset in the Cu/Zn-SOD mutant G93A mouse.  Muscle Nerve 2005;31:214-20. (Impact factor, 2.594; Cited 10 times)


 


32.     Hamadeh MJ, Hoffer LJ.  Effect of protein restriction on sulfur amino acid catabolism in insulin-dependent diabetes mellitus.  Am J Physiol Endocrinol Metab 2003;284:E382-9.


 


33.     Hamadeh MJ, Schiffrin A, Hoffer LJ.  Sulfate production depicts fed-state adaptation to protein restriction in humans.  Am J Physiol Endocrinol Metab 2001;281:E341-8.


 


34.     Hamadeh MJ, Hoffer LJ.  Effect of protein restriction on 15N transfer from dietary [15N]alanine and [15N]Spirulina platensis into urea.  Am J Physiol Endocrinol Metab 2001;281:E349-56.


 


35.     Hamadeh MJ, Hoffer LJ.  Use of sulfate production as a measure of short-term sulfur amino acid catabolism in humans.  Am J Physiol Endocrinol Metab 2001;280:E857-66.


 


36.     Hoffer LJ, Kaplan LN, Hamadeh MJ, Grigoriu AC, Baron M.  Sulfate could mediate the therapeutic effect of glucosamine sulfate.  Metabolism 2001;50:767-70.


 


37.     Hamadeh MJ, Robitaille L, Boismenu D, Hongsprabhas P, Mamer OA, Hoffer LJ.  Human extracellular water volume can be measured using the stable isotope Na234SO4.  J Nutr 1999;129:722-9.


 


38.     Hamadeh MJ, Hoffer LJ.  Tracer methodology underestimates changes in plasma urea appearance in humans.  Am J Physiol 1998;274:E547-53.


 


39.     Hoffer LJ, Taveroff A, Hamadeh MJ.  Dietary protein restriction alters glucose but not protein metabolism in non-insulin-dependent Diabetes Mellitus.  Metabolism 1998;47 (9):1145-51.


 


40.     Boismenu D, Robitaille L, Hamadeh MJ, Hongsprabhas P, Hoffer LJ, Mamer OA.  Measurement of sulfate concentrations and tracer/tracee ratios in biological fluids by electrospray tandem mass spectrometry.  Anal Biochem 1998;261:93-9.


 


41.     Hoffer LJ, Taveroff A, Robitaille L, Hamadeh MJ, Mamer O.  Effects of leucine on whole-body leucine, valine and threonine metabolism in humans.  Am J Physiol 1997;272:E1037-42.


 


42.     Cunnane SC, Hamadeh MJ, Liede AC, Thompson LU, Wolever TMS.  Nutritional attributes of traditional flaxseed in healthy young adults.  Am J Clin Nutr 1995;61:62-8.


 


43.     Cunnane SC, Ganguli S, Menard C, Liede AC, Hamadeh MJ, Chen Z-Y, Wolever TMS, Jenkins DJA.  High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans.  Br J Nutr 1993;69:443-53.


 


44.     Cunnane SC, Chen Z-Y, Yang J, Liede AC, Hamadeh M. Alpha-linolenic acid in Humans: Direct functional role or dietary precursor.  Nutrition 1991;7 (6):437-9.


 


BOOKS


1.         Hamadeh MJ, Adegoke OAJ. Enhancing the Understanding of Human Nutrition: A student guide to Understanding Nutrition. Nelson Education Ltd, Toronto, ON, 2009, pp.176. (ISBN 0176478078).


 


PEER-REFEREED REPORTS


1.      Zukier Z, Solomon JA, Hamadeh MJ. The role of nutrition in mental health: Suicide. Canadian Mental Health Association, Toronto, ON, 2011.


      http://www.mindingourbodies.ca/about_the_project/literature_reviews/suicide_and_nutrition


 


2.      Zukier Z, Solomon JA, Hamadeh MJ. The role of nutrition in mental health: Attention deficit hyperactivity disorder (ADHD). Canadian Mental Health Association, Toronto, ON, 2010. http://www.mindingourbodies.ca/about_the_project/literature_reviews/adhd_and_nutrition


 


3.      Solomon JA, Zukier Z, Hamadeh MJ. The role of nutrition in mental health: Depression. Canadian Mental Health Association, Toronto, ON, 2010. http://www.mindingourbodies.ca/about_the_project/literature_reviews/depression_and_nutrition












Other Research Outputs

ABSTRACTS

1.        Taheri-Shalmani S, Shahsavar S, Gianforcaro A, Solomon JA, Hamadeh MJ. Vitamin D3 megadose decreases endoplasmic reticulum stress while paradoxically increasing apoptosis, suggesting toxicity, in the female transgenic G93A mouse model of amyotrophic lateral sclerosis. Ontario Exercise Physiology Conference 2013:31 (abst.).

 

2.         Shahsavar S, Taheri-Shalmani S, Solomon JA, Gianforcaro A, Hamadeh MJ. Dietary vitamin D3 restriction at 0.025x the adequate intake increases endoplasmic reticulum (ER) stress in the skeletal muscle of the male transgenic G93A mouse model of amyotrophic lateral sclerosis (ALS), whereas it decreases calbindin d28k and increases both ER stress and apoptosis in the female transgenic G93A mouse model of ALS. Ontario Exercise Physiology Conference 2013:30 (abst.).

 

3.         Gianforcaro A, Solomon JA, Parkhomenko E, Porras D, Qamaruzzaman A, Thampinathan B, Provad P, Hamadeh MJ. Cholecalciferol supplementation at 50 fold the adequate intake slows paw grip endurance deterioration but could be toxic for females in the G93A mouse model of amyotrophic lateral sclerosis. 3rd Annual Muscle Health Awareness Day 2012:13 (abst.). http://www.yorku.ca/mhrc/documents/5.MHAD3posterpresentationsmAY222012.pdf

 

4.         Solomon JA, Gianforcaro A, Parkhomenko E, Porras D, Qamaruzzaman A, Thampinathan B, Provad P, Hamadeh MJ.  Muscle weights positively correlate with age at disease onset in the G93A mouse model of ALS. 3rd Annual Muscle Health Awareness Day 2012:23 (abst.). http://www.yorku.ca/mhrc/documents/5.MHAD3posterpresentationsmAY222012.pdf

 

5.         Milionis A, Parkhomenko E, Solomon JA, Gianforcaro A, Hamadeh MJ. Vitamin D3 deficiency influences skeletal muscle troponin-C and alpha-actin in the transgenic G93A mouse model of ALS. 3rd Annual Muscle Health Awareness Day 2012:17 (abst.). http://www.yorku.ca/mhrc/documents/5.MHAD3posterpresentationsmAY222012.pdf

 

6.         Parkhomenko E, Milionis A, Gianforcaro A, Solomon JA, Hamadeh MJ. Dietary D3 supplementation at 50x the AI increases contractile protein content and improves mitochondrial oxidative capacity in the transgenic G93A mouse model of ALS: a pilot study. 3rd Annual Muscle Health Awareness Day 2012:18 (abst.). http://www.yorku.ca/mhrc/documents/5.MHAD3posterpresentationsmAY222012.pdf

 

7.         Parkhomenko E, Milionis A, Gianforcaro A, Solomon JA, Hamadeh MJ. Dietary vitamin D3 at 50x the adequate intake increases apoptosis in the quadriceps of the female G93A mouse model of amyotrophic lateral sclerosis: a pilot study. FASEB J 2012;26:255.7 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/255.7?sid=86d0570c-a5a8-4da7-834e-2375b879a7c0

 

8.         Milionis A, Parkhomenko E, Solomon JA, Gianforcaro A, Hamadeh MJ. Dietary vitamin D3 restriction differentially alters quadriceps contractile proteins in both sexes in the transgenic G93A mouse model of amyotrophic lateral sclerosis: a pilot study. FASEB J 2012;26:255.8 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/255.8?sid=86d0570c-a5a8-4da7-834e-2375b879a7c0

 

9.         Parkhomenko EA, Gianforcaro A, Solomon JA, Porras D, Qamaruzzaman A, Thampinathan B, Provad P, Hamadeh MJ. Dietary vitamin D3 megadose and restriction modulate oxidative damage, antioxidant capacity and inflammation in the transgenic G93A mouse model of amyotrophic lateral sclerosis (ALS): A pilot study. Ontario Exercise Physiology Conference 2012:23 (abst.).

 

10.     Parkhomenko EA, Gianforcaro A, Solomon JA, Hamadeh MJ. Vitamin D deficiency improves antioxidant capacity in males and attenuates the sexual dichotomy in the G93A mouse model of amyotrophic lateral sclerosis: is the female sex at D3-deficient disadvantage? Appl Physiol Nutr Metab 2011;36:474 (abst.). http://www.nrcresearchpress.com/doi/pdfplus/10.1139/h11-034

 

11.     Parkhomenko EA, Gianforcaro A, Solomon JA, Hamadeh MJ. Dietary vitamin D3 at 50 fold the adequate intake increases antioxidant capacity and decreases inflammation in the G93A mouse model of ALS. Appl Physiol Nutr Metab 2011;36:474 (abst.). http://www.nrcresearchpress.com/doi/pdfplus/10.1139/h11-034

 

12.     Gianforcaro A, Solomon JA, Hamadeh MJ. Vitamin D3 supplementation at 50x the adequate intake attenuates functional decline in the transgenic G93A mouse model of amyotrophic lateral sclerosis: have females reached their threshold for toxicity? FASEB J 2011;25:343.3 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/343.3?sid=5573fda3-9827-42d2-9ece-fe108de3680b

 

13.     Solomon JA, Gianforcaro A, Hamadeh MJ. A diet deficient in vitamin D3 delays disease onset in the female, but not the male, G93A mouse model of amyotrophic lateral sclerosis. FASEB J 2011;25:218.2 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/218.2?sid=5573fda3-9827-42d2-9ece-fe108de3680b

 

14.     Gianforcaro A, Hamadeh MJ. Vitamin D3 at 10x the AI attenuates the decline in functional outcomes in an animal model of ALS. First International Online Annual Conference of Models of Human Diseases. Toronto, ON, June 29, 2010.  http://www.veterinarybioscienceinstitute.com/resources.php?id=46&p=1&site_cat=26 http://eportal.vetbiotech.com/uploads/ufile661.pdf

 

15.     Solomon JA, Hamadeh MJ. When is endpoint achieved in a mouse model of ALS? First International Online Annual Conference of Models of Human Diseases. Toronto, ON, June 29, 2010. http://www.veterinarybioscienceinstitute.com/resources.php?id=46&p=1&site_cat=26 http://eportal.vetbiotech.com/uploads/ufile654.pdf

 

16.     Samjoo IA, Safdar A, Hamadeh MJ, Glover AW, Mocellin NJ, Santana J, Steinberg GR, Raha S, Gallagher I, Timmons JA, Tarnopolsky MA. Endurance training augments skeletal muscle mitochondrial function and improves insulin resistance by modulating inflammation in obese men. Proceedings of the 2nd Canadian Obesity Student Meeting 2010:24 (abst.). http://www.studentobesitymeeting.ca/files/COSM_Program_7_web.pdf

 

17.     Solomon JA, Hamadeh MJ. Neuromuscular disease and ethics: considerations of endpoint in a mouse model of Lou Gehrig’s disease. Muscle Health Awareness Day 2010:34 (abst.). http://www.yorku.ca/mhrc/documents/MHADprogMay282010.pdf

 

18.     Gianforcaro A, Hamadeh MJ. Is adequate really enough? Vitamin D3 supplementation at 10x the AI blunts disease severity and enhances functional outcomes in an animal model of Lou Gehrig’s disease. A pilot study. Muscle Health Awareness Day 2010:19 (abst.). http://www.yorku.ca/mhrc/documents/MHADprogMay282010.pdf

 

19.     Gianforcaro A, Hamadeh MJ. D throws Lou Gehrig’s a curveball: D3 attenuates disease severity and functional decline. Bodies of Knowledge Graduate Research Conference 2010:15 (abst.).

         http://www.physical.utoronto.ca/faculty_research/grad/Final%20Final%20conference%20program%202010.pdf

 

20.     Solomon JA, Hamadeh MJ. Does vitamin D and calcium supplementation have an effect on markers of type 2 diabetes? – A proposed clinical trial. Bodies of Knowledge Graduate Research Conference 2010:14 (abst.).

         http://www.physical.utoronto.ca/faculty_research/grad/Final%20Final%20conference%20program%202010.pdf

 

21.     Solomon JA, Hamadeh MJ. Does D Deliver in Diabetics? A Proposed double blind randomized control trial. Proceedings of the 2010 YIHR Graduate Student Symposium http://www.yorku.ca/yihr/Students/StudentSymposium/index.html (abst.).

 

22.     Samjoo IA, Safdar A, Hamadeh MJ, Raha S, Kujoth GC, Prolla TA, Tarnopolsky MA. Mitochondrial Dysfunction is Not a Causative Factor in the Pathogenesis of Obesity. FASEB J  2010;24:1045.9 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/1045.9?sid=8df2b65b-accf-42f0-aaec-70aad2cb1593

 

23.     Samjoo IA, Safdar A, Hamadeh MJ, Akhtar M, Raha S, Timmons JA, Tarnopolsky MA. Endurance Training-mediated Differential Regulation of miRNAs in Skeletal Muscle of Lean and Obese Men. FASEB J 2010;24:806.14 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/806.14?sid=8df2b65b-accf-42f0-aaec-70aad2cb1593

 

24.     Gianforcaro A, Hamadeh MJ. Dietary vitamin D3 at 10 fold the adequate intake may attenuate disease severity in the transgenic G93A mouse model of ALS. FASEB J 2010 24:lb396 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/lb396?sid=8df2b65b-accf-42f0-aaec-70aad2cb1593

 

25.     Gianforcaro A, Hamadeh MJ. The effect of vitamin D on the G93A Mouse model of ALS. Proceedings of the Ontario Exercise Physiology Conference 2010:32 (abst.).

 

26.     Solomon JA, Hamadeh MJ. The role of vitamin D and calcium supplementation in modulating the pathogenesis of type 2 diabetes mellitus. Proceedings of the Ontario Exercise Physiology Conference 2010:58 (abst.).

 

27.     Hamadeh MJ, Seevaratnam R. Coffee and caffeine decrease markers of oxidative stress in G93A mice: coffee improves antioxidant enzyme capacity in males. Ann Nutr Metab 2009;55(Suppl.1):190 (abst.).

 

28.     Ma X, Hamadeh MJ, Foster J, Tarnopolsky MA. Brain derived neurotrophic factor promotes cell survival and neuronal differentiation in the dentate gyrus of G93A mice. Appl Physiol Nutr Metab 2009;34:1142 (abst.). http://www.nrcresearchpress.com/doi/pdf/10.1139/h09-114

 

29.     Samjoo IA, Hamadeh MJ, Santana J, Raha S, Tarnopolsky MA. Obesity does not impair mitochondrial adaptations to endurance exercise. Appl Physiol Nutr Metab 2009;34:1154 (abst.). http://www.nrcresearchpress.com/doi/pdf/10.1139/h09-114

 

30.     Seevaratnam R, Raha S, Tarnopolsky MA, Hamadeh MJ. Coffee, caffeine, and chlorogenic acid reduce oxidative stress and apoptosis, and improve antioxidant enzyme capacity in male G93A mice, an animal model of amyotrophic lateral sclerosis (ALS). Proceedings of the CSCN-CSNS Annual Scientific Meeting 2009:138 (abst.).

 

31.     Seevaratnam R, Raha S, Tarnopolsky MA, Hamadeh MJ. Caffeine increases apoptosis and decreases antioxidant enzyme capacity, in spite of decreasing markers of oxidative stress in female G93A mice, an animal model of amyotrophic lateral sclerosis (ALS). Proceedings of the CSCN-CSNS Annual Scientific Meeting 2009:276 (abst.).

 

32.     Patel BP, Tarnopolsky MA, Hamadeh MJ. Long-term caloric restriction increases apoptosis and decreases cell stress response, despite an elevation in antioxidant enzyme capacity in the skeletal muscle of the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS. FASEB J 2009;23:109.1 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/109.1?sid=49e4d16e-d193-4523-a855-a4e9925e1e80

 

33.     Seevaratnam R, Raha S, Tarnopolsky MA, Hamadeh MJ. Caffeine reduces motor performance and antioxidant enzyme capacity in the brain of female G93A mice, an animal model of amyotrophic lateral sclerosis (ALS). FASEB J 2009;23:963.3 (abst.).  http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/963.3?sid=cad3e9e1-2c3a-4a3b-89b8-d0f9da552467

 

34.     Seevaratnam R, Raha S, Tarnopolsky MA, Hamadeh MJ. Coffee increases antioxidant enzyme capacity in the brain of male G93A mice, an animal model of amyotrophic lateral sclerosis (ALS). FASEB J 2009;23:109.6 (abst.). http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/109.6?sid=cad3e9e1-2c3a-4a3b-89b8-d0f9da552467

 

35.     Patel BP, Tarnopolsky MA, Hamadeh MJ. Caloric restriction increases skeletal muscle apoptosis in the G93A mouse due to impairment in cell stress response and an incomplete compensatory upregulation of antioxidant enzymes. Proceedings of the Ontario Exercise Physiology Conference 2009:27 (abst.).

 

36.     Seevaratnam R, Raha S, Tarnopolsky MA, Hamadeh MJ. American Society for Nutriton - ASN

ALS Society of Canada

Canadian Nutrition Society - CNS

Canadian Society for Exercise Physiology - CSEP

Supervision

Currently available to supervise graduate students: Yes

Currently taking on work-study students, Graduate Assistants or Volunteers: Not Indicated

Available to supervise undergraduate thesis projects: No

Current Research

-  Dietary interventions (Long-term and short-term caloric restriction;  coffee, caffeine and chlorogenic acid; vitamin D) on functional, disease and molecular outcome measures (oxidative stress, inflammation, apoptosis, cellular redox, mitochondrial bioenergetics and neuron count) in the mouse model of amyotrophic lateral sclerosis (ALS; Lou Gehrig’s), with special emphasis on sex differences  

-  Correlation of diet with the progression of disease in ALS patients

 -  Vitamin D and calcium supplementation in type 2 diabetic subjects on insulin resistance, glucose tolerance, and carbohydrate and protein metabolism