Olivier BIROT

Associate Professor

Locations / Contact Info:

353 Norman Bethune College - BC
Keele Campus
Phone: 416 736 2100 Ext. 44043

Locations / Contact Info:

423
Keele Campus
Phone (Life Science Building (LSB)): 416 736 2100 Ext. 44819

Email address(es):

birot@yorku.ca

Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science

Degrees

Habilitation à Diriger des Recherches HDR - 2009
Université Claude Bernard
Lyon, France

Postdoctoral training - 2006
Karolinska Institutet
Stockholm, Sweden

PhD in Physiology - 2003
Université Claude Bernard
Lyon, France

Selected Publications

Amouzou C, Breuker C, Fabre O, Bourret A, Lambert K, Birot O, Fédou C, Dupuy AM, Cristol JP, Sutra T, Molinari N, Maimoun L, Mariano-Goulart D, Galtier F, Avignon A, Stanke-Labesque F, Mercier J, Sultan A, Bisbal C. Skeletal muscle insulin resistance and absence of inflammation characterize insulin-resistance grade I obese women. PLoS One, 11(4), 2016



 



Aiken J, Roudier E, Ciccone J, Drouin G, Stromberg A, Vojnovic J, Olfert IM, Haas T, Gustafsson T, Grenier G, Birot O. Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression. FASEB J. 2016 Mar;30(3):1120-34. doi: 10.1096/fj.15-276964. Epub 2015 Nov 17.



 



Roudier E, Aiken J, Slopack Dara, Gouzi F, Mercier J, Haas TL, Gustaffson T, Hayot M, Birot, O. Novel perspective:  Exercise training stimulus triggers the expression of the oncoprotein Human Double Minute-2 in human skeletal muscle. Physiological Reports 1, 2014



 



Gouzi F, Prefaut C, Abdellaoui A, Roudier E, de Rigal P, Molinari N, Laoudj-Chenivesse D, Mercier J, Birot O, Hayot M. Blunted muscle angiogenic training-response in COPD patients versus sedentary controls. European Respiratory Journal 41:806-14, 2013 



 



 



Roudier E, Forn P, Perry ME, Birot O. Murine Double Minute-2 is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle. FASEB Journal 26:4530-4539, 2012 



 



 



Roudier E, Gineste C, Wazna A, Dehghan K, Desplanches D, Birot O. Angio-adaptation in unloaded skeletal muscle: New insights into an early and muscle-specific dynamic process. Journal of Physiology (London) 588: 4579-4591, 2010



 



Holmgren L, Ambrosino E, Birot O, Tullus C, Veitonmäkii N, Carlson L-M, Forni G and Kiessling R. A DNA vaccine targeting the angiostatin receptor angiomotin inhibits angiogenesis and suppresses tumor growth. Proc. Natl. Acad. Sci. USA 103: 9208-13, 2006


Affiliations

Angiogenesis Research Group, York University
co-Founder and co-Principal Investigator

Partnerships

Karolinska Institutet
Co-investigator on various projets

Service/Community Activities

Canadian Institute for Military & Veteran Health Research
College of Peer Reviewers

Supervision

Currently available to supervise graduate students: No

Currently taking on work-study students, Graduate Assistants or Volunteers: No

Available to supervise undergraduate thesis projects: No

Current Research

Cellular and molecular mechanisms regulating muscle angio-adaptation under physio- and pathological conditions.