Ali Abdul-Sater

Assistant Professor

Locations / Contact Info:

341 Norman Bethune College - BC
Keele Campus
Phone: 4167362100 Ext. 77226

Locations / Contact Info:

205 Farquharson Life Sciences - FARQ
Keele Campus
Phone: 4167362100 Ext. 77320

Email address(es):

aasater@yorku.ca

Faculty & School/Dept.

Faculty of Health

Degrees

Ph. D. - 2010
University of California
Merced, CA - USA

M. Sc. - 2005
American University of Beirut
Beirut, Lebanon

B. Sc. - 2003
Haigazian University
Beirut, Lebanon

Selected Publications

Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH. The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease. Nature Immunology 2017 ;18(1): 26-35. doi: 10.1038/ni.3618. 



Chang YH, Wang KC, Chu KL, Clouthier DL, Tran AT, Torres Perez MS, Zhou AC, Abdul-Sater AA, Watts TH. Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity. Immunity, 2017; 47(5):943-958 â€¨



Abdul-Sater AA, Majoros A, Plumlee CR, Perry S, Gu AD, Lee C, Shresta S, Decker T, Schindler C. Different STAT transcription complexes drive early and delayed responses to type I Interferons.  The Journal of Immunology, 2015 Jul 1;195(1):210-6



Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C. Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Reports 2013 Oct;14(10):900-6



Abdul-Sater, A. A., Grajkowski, A., Erdjument-Bromage, H., Plumlee, C., Levi, A., Schreiber, M. T., Lee, C., Shuman, H., Beaucage, S. L. & Schindler, C. The overlapping host responses to bacterial cyclic dinucleotides. Microbes and Infection 2012 Feb;14(2):188-97.



Abdul-Sater, A. A., Said-Sadier, N., Lam, V. M., Singh, B., Pettengill, M. A., Soares, F., Tattoli, I., Lipinski, S., Girardin, S. E., Rosenstiel, P. & Ojcius, D. M. Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1. Journal of Biological Chemistry, 2010 Dec 31;285(53):41637-45.



Abdul-Sater, A. A., Said-Sadier, N., Padilla, E. V. & Ojcius, D. Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome. Microbes and Infection, 2010 Aug;12(8-9):652-61.



Abdul-Sater, A. A., Koo, E., Hacker, G. & Ojcius, D. M. Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. Journal of Biological Chemistry, 2009 Sep 25;284(39):26789-96.



Sater, A. A., Ojcius, D. M. & Meyer, M. P. Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity. Antimicrobial Agents and Chemotherapy, 2008 Jul;52(7):2660-2.



Seror, C., Melki, M. T., Subra, F., Raza, S. Q., Bras, M., Saidi, H., Nardacci, R., Voisin, L., Paoletti, A., Law, F., Martins, I., Amendola, A., Abdul-Sater, A. A., Ciccosanti, F., Delelis, O., Niedergang, F., Thierry, S., Said-Sadier, N., Lamaze, C., Metivier, D., Estaquier, J., Fimia, G. M., Falasca, L., Casetti, R., Modjtahedi, N., Kanellopoulos, J., Mouscadet, J. F., Ojcius, D. M., Piacentini, M., Gougeon, M. L., Kroemer, G. & Perfettini, J. L. Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection. Journal of Experimental Medicine, 2011 Aug 29;208(9):1823-34. 



Ali Abdul Sater*, Matthew A Pettengill*, Robson Coutinho-Silva, David M Ojcius. Danger Signals, Inflammasomes, and the Intricate Intracellular Lives of Chlamydiae. , Biomedical JournalJuly 2016 (In Press) *co-first authors



Ali A Abdul-Sater and Dana J Philpott. Inflammasomes. Encyclopedia of Immunobiology 2016 (In Press)



Abdul-Sater, A. A. & Schindler, C. Interferon regulation of the innate response to bacteria. Jak-Stat Signaling : From Basics to Disease. DOI 10.1007/978-3-7091-0891-8_22, # Springer-Verlag/Wien 2012 (Book Chapter)



Abdul-Sater, A. A., Said-Sadier, N., Ojcius, D. M., Yilmaz, O. & Kelly, K. A. Inflammasomes bridge signaling between pathogen identification and the immune response. Drugs of Today (Barc), 2009 Nov;45 Suppl B:105-12. Review.


Affiliations

Canadian Society for Immunology (CSI)

International Cytokine and Interferon Society (ICIS)

International Society of Exercise and Immunology (ISEI)

Supervision

Currently available to supervise graduate students: Yes

Currently taking on work-study students, Graduate Assistants or Volunteers: No

Available to supervise undergraduate thesis projects: No

Current Research

Our lab is interested in identifying novel regulators of inflammation and understanding the molecular mechanisms through which these regulators control innate immunity and the inflammatory response. We are currently pursruing several avenues of research, and they include:

1) Investigating the molecular mechanisms through which different exercise regimens regulate the immune response.

2) Understanding the disparate roles of TRAF1 in controlling chronic inflammatory and autoimmune diseases.

3) Assessing the role of individual Type I interferons in bacterial and viral responses.